:root {
  --navy: #07366f;
  --deep: #183847;
  --teal: #009a94;
  --aqua: #45d1d4;
  --orange: #f26b38;
  --purple: #7b3f8c;
  --cream: #f6ecd9;
  --paper: #fbfaf6;
  --ink: #183847;
  --muted: #637078;
  --line: #d9e0e0;
  --white: #ffffff;
  --max: 1180px;
}

*,
*::before,
*::after {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
  -webkit-text-size-adjust: 100%;
  text-size-adjust: 100%;
}

body {
  margin: 0;
  font-family: Helvetica, Arial, sans-serif;
  color: var(--ink);
  background: var(--paper);
  line-height: 1.5;
  font-synthesis: none;
  text-rendering: optimizeLegibility;
  -webkit-font-smoothing: antialiased;
}

a {
  color: inherit;
  text-decoration: none;
}

img {
  max-width: 100%;
}

h1,
h2,
h3,
p {
  margin-top: 0;
}

h1,
h2,
h3 {
  line-height: 1.04;
  letter-spacing: -0.03em;
}

h1 {
  margin-bottom: 34px;
  font-size: 72px;
  font-weight: 700;
  max-width: 1040px;
}

h2 {
  margin-bottom: 26px;
  font-size: 52px;
  font-weight: 700;
  max-width: 1030px;
}

h3 {
  font-size: 22px;
  font-weight: 700;
}

p {
  font-size: 17px;
}

.container {
  width: calc(100% - 44px);
  max-width: var(--max);
  margin: 0 auto;
}

.section {
  padding: 112px 0;
  scroll-margin-top: 78px;
}

.eyebrow {
  margin-bottom: 18px;
  font-size: 12px;
  font-weight: 700;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}

.lede {
  max-width: 900px;
  font-size: 22px;
  line-height: 1.48;
}

.small {
  font-size: 13px;
}

.muted {
  color: var(--muted);
}

.accent {
  color: var(--orange);
}

/* Header */
nav {
  position: sticky;
  top: 0;
  z-index: 20;
  background: #fff;
  border-bottom: 1px solid var(--line);
}

.navinner {
  height: 76px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 18px;
}

.brand {
  height: 76px;
  display: flex;
  align-items: center;
}

.brand img {
  display: block;
  width: auto;
  height: 76px;
}

.navlinks {
  display: flex;
  align-items: center;
  gap: 22px;
  font-size: 14px;
  font-weight: 700;
}

.navcta {
  padding: 9px 14px;
  border: 1px solid var(--deep);
  border-radius: 999px;
}

/* Hero */
.hero {
  min-height: calc(100vh - 76px);
  display: flex;
  align-items: center;
  position: relative;
  overflow: hidden;
  color: #fff;
  background: linear-gradient(135deg, var(--deep) 0%, #123f53 58%, #0b6d70 115%);
}

.hero::before,
.hero::after {
  content: "";
  position: absolute;
  border-radius: 50%;
  pointer-events: none;
}

.hero::before {
  width: 620px;
  height: 620px;
  right: -110px;
  top: -290px;
  border: 1px solid rgba(69, 209, 212, 0.28);
  box-shadow:
    0 0 0 85px rgba(69, 209, 212, 0.035),
    0 0 0 170px rgba(69, 209, 212, 0.025);
}

.hero::after {
  width: 430px;
  height: 430px;
  right: 180px;
  bottom: -280px;
  border: 1px solid rgba(69, 209, 212, 0.22);
}

.hero .container {
  position: relative;
  z-index: 2;
}

.hero .lede {
  max-width: 860px;
  margin-bottom: 0;
  color: #edf5f4;
}

.actions {
  display: flex;
  flex-wrap: wrap;
  gap: 12px;
  margin-top: 30px;
}

.button {
  display: inline-flex;
  align-items: center;
  gap: 8px;
  padding: 13px 18px;
  border: 1px solid currentColor;
  border-radius: 999px;
  font-size: 16px;
  font-weight: 700;
  line-height: 1;
}

.button.light {
  background: #fff;
  border-color: #fff;
  color: var(--deep);
}

.proofbar {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 1px;
  margin-top: 54px;
  overflow: hidden;
  border: 1px solid rgba(255,255,255,.18);
  border-radius: 18px;
  background: rgba(255,255,255,.18);
}

.proofbar > div {
  min-height: 78px;
  display: flex;
  align-items: center;
  padding: 20px 22px;
  background: rgba(9, 44, 57, 0.28);
}

.proofbar strong {
  font-size: 17px;
  font-weight: 700;
  letter-spacing: 0;
}

/* Clinical need */
.need {
  background: var(--cream);
}

.needcopy {
  max-width: 980px;
  margin-top: 34px;
}

.needcopy .lede {
  max-width: 980px;
}

.riskgrid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 14px;
  margin-top: 38px;
}

.risk {
  min-height: 82px;
  display: flex;
  align-items: center;
  padding: 20px;
  background: #fff;
  border: 1px solid var(--line);
  border-radius: 16px;
}

.risk b {
  margin: 0;
  font-size: 16px;
  font-weight: 700;
  letter-spacing: 0.01em;
}

/* Treatment gap */
.limits {
  background: var(--paper);
}

.classgrid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 14px;
  margin-top: 38px;
}

.classcard {
  min-height: 190px;
  padding: 22px;
  background: #fff;
  border: 1px solid var(--line);
  border-radius: 18px;
}

.classcard h3 {
  margin-bottom: 14px;
}

.classcard p {
  margin-bottom: 0;
}

.aftergrid.single-column {
  display: block;
  width: 100%;
  margin-top: 34px;
}

.aftergrid.single-column .gap-copy {
  max-width: none;
  margin: 0 0 16px 0;
  color: inherit;
  font-size: 18px;
  font-weight: 400;
  line-height: 1.55;
}

.aftergrid.single-column .gap-copy:last-child {
  margin-bottom: 0;
}

/* Mechanism */
.science {
  color: #f7fbfa;
  background: var(--deep);
}

.science .lede {
  max-width: 960px;
  color: #dceceb;
}

.mechanism {
  max-width: 980px;
  margin: 40px auto 0;
  display: grid;
  grid-template-columns: 1fr auto 1fr;
  align-items: center;
  gap: 26px;
  padding: 34px;
  background: #080a0b;
  border-radius: 24px;
}

.mechanism > div {
  min-width: 0;
}

.mechanism img {
  width: 100%;
  height: auto;
  display: block;
  border-radius: 14px;
}

.mechanism .arrow {
  color: var(--orange);
  font-size: 40px;
  font-weight: 700;
}

.mechlabel {
  margin-top: 15px;
  color: #fff;
  text-align: center;
  font-size: 16px;
  line-height: 1.25;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.sciencepoints {
  max-width: 980px;
  margin: 22px auto 0;
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 14px;
}

.sciencepoint {
  min-height: 100px;
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  padding: 22px;
  text-align: center;
  background: rgba(255,255,255,.06);
  border: 1px solid rgba(255,255,255,.16);
  border-radius: 18px;
}

.sciencepoint b {
  font-size: 17px;
  font-weight: 700;
  letter-spacing: 0.02em;
  text-transform: uppercase;
}

.sciencepoint .science-footnote {
  max-width: 350px;
  margin: 10px 0 0;
  color: #d8efec;
  font-size: 13px;
  font-weight: 400;
  line-height: 1.35;
  letter-spacing: 0;
  text-transform: none;
}

/* Platform */
.pipeline {
  background: #fff;
}

.milestones {
  display: grid;
  grid-template-columns: repeat(3, 1fr);
  gap: 14px;
  margin: 34px 0 28px;
}

.milestone {
  min-height: 150px;
  padding: 22px;
  background: var(--paper);
  border: 1px solid var(--line);
  border-radius: 18px;
}

.milestone strong {
  display: block;
  margin-bottom: 10px;
  font-size: 20px;
  font-weight: 700;
}

.milestone span {
  display: block;
  font-size: 15px;
  line-height: 1.5;
}

.platformintro {
  max-width: 940px;
  margin: 20px 0 30px;
}

.platformintro .lede {
  max-width: 940px;
}

.tablewrap {
  overflow-x: auto;
  margin-top: 28px;
  border: 1px solid var(--line);
  border-radius: 18px;
}

table {
  width: 100%;
  min-width: 900px;
  border-collapse: collapse;
}

th,
td {
  padding: 18px 19px;
  vertical-align: top;
  text-align: left;
  border-bottom: 1px solid var(--line);
}

th {
  background: var(--paper);
  font-size: 12px;
  font-weight: 700;
  letter-spacing: 0.09em;
  text-transform: uppercase;
}

td {
  font-size: 15px;
}

tbody tr:last-child td {
  border-bottom: 0;
}

.stage {
  font-weight: 700;
}

.stage.clinical {
  color: var(--teal);
}

.stage.preclinical {
  color: var(--orange);
}

.stage.research {
  color: var(--muted);
}

.platform-summary {
  max-width: 920px;
  margin: 26px 0 0;
  font-size: 17px;
  font-weight: 700;
}

.science-cta {
  margin-top: 22px;
}

/* Development milestones */
.path {
  color: #fff;
  background: var(--orange);
}

.path .lede {
  color: #fff4ef;
}

.pathgrid {
  display: grid;
  grid-template-columns: 0.9fr 1.1fr;
  gap: 66px;
  align-items: start;
}

.steps {
  display: grid;
  gap: 14px;
}

.step {
  padding: 22px;
  background: rgba(255,255,255,.09);
  border: 1px solid rgba(255,255,255,.28);
  border-radius: 18px;
}

.step .tag {
  margin-bottom: 8px;
  font-size: 12px;
  font-weight: 700;
  letter-spacing: 0.1em;
  text-transform: uppercase;
}

.step h3 {
  margin-bottom: 10px;
}

.step p {
  margin-bottom: 0;
}

/* Partners */
.partners {
  color: #fff;
  background: #101e25;
}

.partners .lede {
  color: #dce5e5;
}

.partnergrid {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 14px;
  margin-top: 36px;
}

.partner {
  padding: 24px;
  background: rgba(255,255,255,.06);
  border: 1px solid rgba(255,255,255,.14);
  border-radius: 18px;
}

.partner h3 {
  margin-bottom: 12px;
}

.partner p {
  margin-bottom: 0;
  color: #dce5e5;
}

/* Team */
.team {
  background: var(--cream);
}

.teamgrid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 14px;
  margin-top: 36px;
}

.person {
  padding: 22px;
  background: #fff;
  border: 1px solid var(--line);
  border-radius: 18px;
}

.person h3 {
  margin-bottom: 7px;
}

.person .role {
  margin-bottom: 12px;
  color: var(--orange);
  font-size: 12px;
  font-weight: 700;
  letter-spacing: 0.09em;
  text-transform: uppercase;
}

.person p {
  margin-bottom: 0;
}

/* Close */
.close {
  text-align: center;
  background: linear-gradient(135deg, var(--paper), #dff0e9);
}

.close h2,
.close .lede {
  margin-left: auto;
  margin-right: auto;
}

.close .actions {
  justify-content: center;
}

/* Footer */
footer {
  padding: 28px 0;
  color: #dfe9e7;
  background: #0e242c;
  font-size: 14px;
}

footer .container {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 24px;
  flex-wrap: wrap;
}

.footerblock {
  display: grid;
  gap: 2px;
}

.footerblock strong {
  color: #fff;
  font-weight: 700;
}

.footerblock span {
  display: block;
}

/* Responsive breakpoints use explicit sizes for cross-browser consistency */
@media (max-width: 1100px) {
  h1 { font-size: 64px; }
  h2 { font-size: 48px; }
  .teamgrid { grid-template-columns: repeat(2, 1fr); }
}

@media (max-width: 900px) {
  h1 { font-size: 54px; }
  h2 { font-size: 42px; }
  .section { padding: 92px 0; }
  .navlinks a:not(.navcta) { display: none; }
  .riskgrid,
  .classgrid,
  .milestones { grid-template-columns: repeat(2, 1fr); }
  .pathgrid { grid-template-columns: 1fr; gap: 34px; }
  .sciencepoints { grid-template-columns: 1fr; }
}

@media (max-width: 700px) {
  h1 { font-size: 46px; }
  h2 { font-size: 36px; }
  .lede { font-size: 20px; }
  .proofbar { grid-template-columns: 1fr; }
  .riskgrid,
  .classgrid,
  .milestones,
  .partnergrid,
  .teamgrid { grid-template-columns: 1fr; }
  .mechanism {
    grid-template-columns: 1fr;
    padding: 24px;
  }
  .mechanism .arrow {
    transform: rotate(90deg);
    justify-self: center;
  }
}

@media (max-width: 520px) {
  .container { width: calc(100% - 30px); }
  .section { padding: 72px 0; }
  .navinner,
  .brand,
  .brand img { height: 62px; }
  .hero { min-height: calc(100vh - 62px); }
  h1 { font-size: 40px; }
  h2 { font-size: 32px; }
  p { font-size: 16px; }
  .lede { font-size: 19px; }
  .button { font-size: 15px; padding: 12px 16px; }
}

/* Final packaging/layout hardening */
.brand {
  flex: 0 0 76px;
  width: 76px;
  min-width: 76px;
  overflow: hidden;
}

.brand img {
  display: block;
  width: 76px;
  height: 76px;
  max-width: 76px;
  object-fit: contain;
}

.navlinks {
  flex: 0 1 auto;
  min-width: 0;
  justify-content: flex-end;
  gap: 20px;
}

.navlinks a {
  display: inline-flex;
  align-items: center;
  white-space: nowrap;
  flex: 0 0 auto;
  line-height: 1;
}

.navcta {
  white-space: nowrap;
  min-width: max-content;
}

/* Step down navigation before any label is allowed to wrap. */
@media (max-width: 1040px) {
  .navlinks { gap: 14px; font-size: 13px; }
  .navcta { padding: 9px 12px; }
}

@media (max-width: 900px) {
  .navlinks a:not(.navcta) { display: none; }
  .navlinks { gap: 0; }
}

@media (max-width: 520px) {
  .brand,
  .brand img {
    width: 62px;
    min-width: 62px;
    height: 62px;
  }
}